ANTIHYPERTENSIVE ACTIVITY OF AN ALKYL ETHER ANALOG OF PHOSPHATIDYLCHOLINE

An alkyl ether analog of phosphatidylcholine was prepared from choline plasmalogen of fresh beef heart by reducing the alk-1-enyl moiety to an alkyl group and by hydrolyzing the sn-2 acyl moiety and replacing it with an acetoyl group. The basis for preparing and testing this compound resulted from experience with antihypertensive lipids derived from the renal medulla and from experience with ether lipid biochemistry. The alkyl lipid analog was found to possess powerful antihypertensive properties in the one-kidney, one-clip hypertensive rats when given either intravenously or orally. This activity induced acute and prolonged depressor effects. These actions were similar to those of a glycerophosphate obtained from fresh renal medulla and designated as APRL (antihypertensive polar renomedullary lipid). © 1979.