DNA REPLICATION IN ABSENCE OF CELL DIVISION IN BUDR-FUDR TREATED HELA CELLS

被引：9

作者：

BERKOVITZ, A

SIMON, EH

TOLIVER, A

机构：

[1] Department of Biological Sciences, Purdue University, Lafayette

来源：

EXPERIMENTAL CELL RESEARCH | 1968年 / 53卷 / 2-3期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0014-4827(68)90319-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

HeLa cells were grown in the presence of 5-bromodeoxyuridine (BUdR) and 5-fluorodeoxyuridine (FUdR). Cell growth studies indicated that under these conditions the cells divided only once, but the results of density centrifugation show that their DNA underwent at least two, and possibly as many as four, cycles of replication. Autoradiographic studies confirmed that no cell division occurred beyond the initial doubling, and showed that the number of nuclei per multinucleated cells increased with time. © 1968.

引用

页码：497 / +

页数：1

共 14 条

[1] INVESTIGATIONS INTO INCORPORATION OF [3H]THYMIDINE INTO DNA IN L-STRAIN CELLS AND FORMATION OF A POOL OF PHOSPHORYLATED DERIVATIVES DURING PULSE LABELLING .I. KINETICS OF [3H]THYMIDINE INCORPORATION .2. INVESTIGATIONS INTO FORMATION OF A POOL OF [3H]THYMIDINE PHOSPHATES DURING PULSE LABELLING [J].