ORGANIZATION OF THE HUMAN GLUT2 (PANCREATIC BETA-CELL AND HEPATOCYTE) GLUCOSE TRANSPORTER GENE

被引：56

作者：

TAKEDA, J

KAYANO, T

FUKOMOTO, H

BELL, GI

机构：

[1] UNIV CHICAGO,HOWARD HUGHES MED INST,5841 S MARYLAND AVE,MC1028,CHICAGO,IL 60637

[2] UNIV CHICAGO,DEPT BIOCHEM & MOLEC BIOL,CHICAGO,IL 60637

[3] UNIV CHICAGO,DEPT MED,CHICAGO,IL 60637

来源：

DIABETES | 1993年 / 42卷 / 05期

关键词：

D O I：

10.2337/diabetes.42.5.773

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The gene encoding the predominant facilitative glucose transporter expressed in pancreatic beta-cells and hepatoctyes, termed GLUT2, has been cloned and characterized. The human GLUT2 gene is composed of 11 exons spanning approximately 30 kilobases. The sequence of the promoter region and all exons and adjacent intron regions has been determined and deposited in the GenBank database. Two highly polymorphic simple tandem repeat DNA polymorphisms useful for linkage studies were localized in introns 1 and 4a. In addition, a 168-base pair insertion/deletion polymorphism was identified in intron 3. The characterization of the human GLUT2 gene will facilitate studies of its role in the development of diabetes mellitus.

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页码：773 / 777

页数：5

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