INHIBITION OF THE GROWTH OF CULTURED HUMAN MENINGIOMA CELLS BY RECOMBINANT INTERFERON-ALPHA

被引:44
作者
KOPER, JW
ZWARTHOFF, EC
HAGEMEIJER, A
BRAAKMAN, R
AVEZAAT, CJJ
BERGSTROM, M
LAMBERTS, SWJ
机构
[1] ERASMUS UNIV,DEPT PATHOL,3000 DR ROTTERDAM,NETHERLANDS
[2] ERASMUS UNIV,DEPT GENET,3000 DR ROTTERDAM,NETHERLANDS
[3] ERASMUS UNIV,DEPT NEUROSURG,3000 DR ROTTERDAM,NETHERLANDS
关键词
D O I
10.1016/0277-5379(91)90375-N
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In this paper the results of investigations on the effect of interferon-alpha (IFN-alpha) on the growth of meningioma cells in culture is reported. A consecutive series of six meningiomas and one meningioma/neurofibroma derived from a patient with neurofibromatosis type 2 was investigated and it was found that the growth of all seven tumours in response to mitotic stimuli (fetal bovine serum or epidermal growth factor) is strongly inhibited by IFN-alpha. Maximal response varied between 100% and 70% inhibition of the incorporation of tritiated thymidine. In some cases an inhibitory response was obtained already at very low doses (less-than-or-equal-to 10 U of IFN-alpha per ml). These results indicate that further clinical investigation of the application of IFN-alpha to the treatment of meningioma is warranted.
引用
收藏
页码:416 / 419
页数:4
相关论文
共 22 条
[1]  
BARON S, 1987, INTERFERON SYSTEM CU
[2]  
BERGSTROM M, 1989, J ENDOCRINOL INVE S2, V12, P91
[3]   PRESENCE OF PROGESTERONE RECEPTORS AND ABSENCE OF ESTROGEN-RECEPTORS IN HUMAN INTRACRANIAL MENINGIOMA CYTOSOLS [J].
BLANKENSTEIN, MA ;
BLAAUW, G ;
LAMBERTS, SWJ ;
MULDER, E .
EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY, 1983, 19 (03) :365-370
[4]   REGULATION OF CELL-PROLIFERATION AND DIFFERENTIATION BY INTERFERONS [J].
CLEMENS, MJ ;
MCNURLAN, MA .
BIOCHEMICAL JOURNAL, 1985, 226 (02) :345-360
[5]   FLUOROMETRIC QUANTIFICATION OF DNA IN CELLS AND TISSUE [J].
DOWNS, TR ;
WILFINGER, WW .
ANALYTICAL BIOCHEMISTRY, 1983, 131 (02) :538-547
[6]  
FICKEL G, 1989, Neurofibromatosis, V2, P57
[7]  
FRIEDMAN RM, 1986, INTERFERONS CELL GRO
[8]   IMPROVED IDENTIFICATION OF CHROMOSOMES OF LEUKEMIC-CELLS IN METHOTREXATE-TREATED CULTURES [J].
HAGEMEIJER, A ;
SMIT, EME ;
BOOTSMA, D .
CYTOGENETICS AND CELL GENETICS, 1979, 23 (03) :208-212
[9]  
Harnden DG, 1985, INT SYSTEM HUMAN CYT