INHIBITION OF DNA-SYNTHESIS IN HARDING-PASSEY MELANOMA-CELLS BY PROSTAGLANDINS-A1 AND A2 - COMPARISON WITH CHEMOTHERAPEUTIC-AGENTS

PGA1 and PGA2 significantly depressed melanoma cell DNA synthesis and cell proliferation in a dose related fashion. Inhibition of DNA synthesis was rapid in onset (0.5-1 hr) and sustained (12 hr). This was not due to general cytotoxicity or depression of substrate uptake. Comparison with known cancer chemotherapeutic agent revealed PGA1 and PGA2 effectiveness on a molar basis exceeded that of Adriamycin, cyclophosphamide and hydroxyurea. Actinomycin D, Mutamycin and 5-fluorouracil were more potent than PGA1 and PGA2 but consideration of their toxicities may outweigh this point. The findings suggest that the A series prostaglandins or their analogs may be efficacious in cancer chemotherapy. © 1979.