REPLICATIVE SENESCENCE - THE HUMAN FIBROBLAST COMES OF AGE

被引：655

作者：

GOLDSTEIN, S

机构：

[1] UNIV ARKANSAS MED SCI HOSP,DEPT BIOCHEM,LITTLE ROCK,AR 72205

[2] JOHN L MCCLELLAN MEM VET ADM MED CTR,GERIATR RES EDUC & CLIN CTR,LITTLE ROCK,AR 72205

[3] UNIV ARKANSAS MED SCI HOSP,DEPT MOLEC BIOL,LITTLE ROCK,AR 72205

来源：

SCIENCE | 1990年 / 249卷 / 4973期

关键词：

D O I：

10.1126/science.2204114

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Human diploid fibroblasts undergo replicative senescence predominantly because of arrest at the G1/S boundary of the cell cycle. Senescent arrest resembles a process of terminal differentiation that appears to involve repression of proliferation-promoting genes with reciprocal new expression of antiproliferative genes, although post-transcriptional factors may also be involved. Identification of participating genes and clarification of their mechanisms of action will help to elucidate the universal cellular decline of biological aging and an important obverse manifestation, the rare escape of cells from senescence leading to immortalization and oncogenesis.

引用

页码：1129 / 1133

页数：5

共 88 条

[1] HUMAN-SKIN FIBROBLASTS INVITRO DIFFERENTIATE ALONG A TERMINAL CELL LINEAGE [J].