REFINING THE TEMPORAL DEFINITION OF AN ASSOCIATION AT THE NEURONAL LEVEL USING LONG-TERM POTENTIATION AND LONG-TERM DEPRESSION IN THE DENTATE GYRUS

被引：13

作者：

HASHEMZADEHGARGARI, H ^{[1
]}

COLBERT, CM ^{[1
]}

LEVY, WB ^{[1
]}

机构：

[1] UNIV VIRGINIA,HLTH SCI CTR,DEPT NEUROL SURG,BOX 420,CHARLOTTESVILLE,VA 22908

来源：

NEUROSCIENCE LETTERS | 1991年 / 126卷 / 01期

关键词：

HIPPOCAMPUS; SYNAPTIC PLASTICITY; LONG-TERM DEPRESSION; ASSOCIATIVE MODIFICATION; DENTATE GYRUS;

D O I：

10.1016/0304-3940(91)90365-Z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study sharpens the temporal definition of an association in the context of long-term synaptic modification of the monosynaptic projections from entorhinal cortex to dentate gyrus in the anesthetized rat. The ipsilateral projection produces a powerful postsynaptic excitation and shows synaptic potentiation following 7.5 ms trains. On the other hand, brief, high-frequency contralateral stimulation just after this powerful postsynaptic excitation is followed by long-term depression (LTD) at the synapses of this pathway. Therefore, based on the differential induction of long-term potentiation (LTP) or LTD, a cell can distinguish associated pre- and postsynaptic activation at a temporal resolution at least as small as 7.5 ms.

引用

页码：37 / 40

页数：4

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