INDUCTION OF SALMONELLA STRESS PROTEINS UPON INFECTION OF MACROPHAGES

被引：395

作者：

BUCHMEIER, NA

HEFFRON, F

机构：

[1] Department of Molecular Biology, Research Institute of Scripps Clinic, San Diego

来源：

SCIENCE | 1990年 / 248卷 / 4956期

关键词：

D O I：

10.1126/science.1970672

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Regulated expression of bacterial genes allows a pathogen to adapt to new environmental conditions within the host. The synthesis of over 30 Salmonella proteins is selectively induced during infection of macrophages. Two proteins induced by Salmonella are the heat shock proteins GroEL and DnaK. Two avirulent, macrophage-sensitive mutants of Salmonella synthesize GroEL and DnaK but fail to synthesize different subsets of proteins normally induced within the macrophage. Enhanced expression of selected Salmonella proteins contributes to bacterial survival within macrophages and may also contribute to the apparent immunodominance of heat shock proteins.

引用

页码：730 / 732

页数：3

共 24 条

[1] NOVEL REGULATORY LOCI CONTROLLING OXYGEN-REGULATED AND PH-REGULATED GENE-EXPRESSION IN SALMONELLA-TYPHIMURIUM [J].