SYNTHESIS OF ACTIVE FORMS OF VITAMIN-D .2. SYNTHESIS OF ANALOGS AND THEIR BIOLOGICAL-ACTIVITIES

被引:11
作者
IKEKAWA, N [1 ]
TAKESHITA, T [1 ]
机构
[1] TEIJIN LTD, DIV MED & PHARMACEUT, TOKYO 100, JAPAN
关键词
D O I
10.5059/yukigoseikyokaishi.37.809
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The recent developments in the synthesis of Vitamin D metabolites have been described in Part I of this series. This review covers the recent advances in the synthesis of analogs of the metabolites including modifications in steroidal ring A and side chain. Biological activites of those analogs and structure-activity relationships are also discussed. © 1979, The Society of Synthetic Organic Chemistry, Japan. All rights reserved.
引用
收藏
页码:809 / 829
页数:21
相关论文
共 90 条
[1]   SYNTHESIS OF 3-EPI-CHOLECALCIFEROL AND 5,6-TRANS-3-EPI-CHOLECALCIFEROL [J].
ABERHART, DJ ;
CHU, JYR ;
HSU, ACT .
JOURNAL OF ORGANIC CHEMISTRY, 1976, 41 (06) :1067-1069
[2]  
BARRETT AGM, 1978, SYNTHESIS-STUTTGART, V10, P748
[3]  
BARRETT AGM, 1977, J CHEM SOC, P1014
[4]   CONVENIENT SYNTHESIS OF 1ALPHA-HYDROXY-VITAMIN-D3 [J].
BARTON, DHR ;
HESSE, RH ;
PECHET, MM ;
RIZZARDO, E .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1973, 95 (08) :2748-2749
[5]   SYNTHETIC USES OF STEROIDAL RING B DIENE PROTECTION - 22,23-DIHYDROERGOSTEROL [J].
BARTON, DHR ;
GUNATILAKA, AAL ;
NAKANISHI, T ;
PATIN, H ;
WIDDOWSON, DA ;
WORTH, BR .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1976, (08) :821-826
[6]   CONFORMATIONAL EQUILIBRIA IN VITAMIN-D - SYNTHESIS AND H-1 AND C-13 DYNAMIC NUCLEAR MAGNETIC-RESONANCE STUDY OF 4,4-DIMETHYLVITAMIN D3, 4,4-DIMETHYL-1 ALPHA-HYDROXYVITAMIN D3, AND 4,4-DIMETHYL-1ALPHA-HYDROXYEPIVITAMIN D3 [J].
BERMAN, E ;
FRIEDMAN, N ;
MAZUR, Y ;
SHEVES, M .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1978, 100 (18) :5626-5634
[7]  
Bontekoe J S, 1970, Int Z Vitaminforsch, V40, P589
[8]  
BORIS A, 1977, American Journal of Medicine, V62, P543, DOI 10.1016/0002-9343(77)90414-4
[9]  
CASTILLO L, 1978, MINER ELECTROL METAB, V1, P198
[10]   (22S)-HYDROXYVITAMIN-D4 [J].
CRUMP, DR ;
WILLIAMS, DH ;
PELC, B .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1973, (22) :2731-2733