HUMAN MELANOTRANSFERRIN (P97) HAS ONLY ONE FUNCTIONAL IRON-BINDING SITE

被引：90

作者：

BAKER, EN ^{[1
]}

BAKER, HM ^{[1
]}

SMITH, CA ^{[1
]}

STEBBINS, MR ^{[1
]}

KAHN, M ^{[1
]}

HELLSTROM, KE ^{[1
]}

HELLSTROM, I ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB,SEATTLE,WA 98121

来源：

FEBS LETTERS | 1992年 / 298卷 / 2-3期

关键词：

IRON BINDING; MELANOTRANSFERRIN; TRANSFERRIN; MELANOMA CELL ANTIGEN;

D O I：

10.1016/0014-5793(92)80060-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The iron-binding properties of melanotransferrin, the tumour-associated antigen also known as p97, have been investigated by UV/visible and fluorescence spectroscopy, amino acid sequence comparison, and modelling. These show that, in contrast to other transferrins, melanotransferrin binds only one Fe3+ ion per molecule. The binding properties of its N-terminal site are similar to other transferrins, but its C-terminal site does not bind iron at all. The differences can be related to specific amino acid changes in the C-terminal site.

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页码：215 / 218

页数：4

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