EFFECT OF DIAZEPAM ON CEREBRAL 5-HYDROXYTRYPTAMINE SYNTHESIS

被引：55

作者：

SANER, A

PLETSCHER, A

机构：

[1] Research Division, F. Hoffmann-La Roche and Co. Ltd.

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 55卷 / 03期

关键词：

5-Hydroxytryptamine; 5-Hydroxytryptophan; Amino-oxyacetic acid; Diazepam; GABA; GABA antagonists;

D O I：

10.1016/0014-2999(79)90200-0

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the brains of normal and reserpinized rats both diazepam and amino-oxyacetic acid (AOAA) decreased the 5-hydroxytryptophan (5HTP) accumulation induced by the decarboxylase inhibitor 3-hydroxybenzylhydrazine (NSD 1015). In reserpinized animals, the action of diazepam was antagonized by picrotoxin and bicuculline in doses which did not themselves influence the NSD 1015-induced rise in 5HTP. In conclusion, diazepam probably depresses 5HT synthesis via GABAergic mechanisms and this effect is not dependent on a functionally intact monoaminergic synaptic transmission. © 1979.

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页码：315 / 318

页数：4

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