RENDERING A MEMBRANE-PROTEIN SOLUBLE IN WATER - A COMMON PACKING MOTIF IN BACTERIAL PROTEIN TOXINS

被引：114

作者：

PARKER, MW ^{[1
]}

PATTUS, F ^{[1
]}

机构：

[1] EUROPEAN MOLEC BIOL LAB,D-69012 HEIDELBERG,GERMANY

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1993年 / 18卷 / 10期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/0968-0004(93)90096-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The recently determined structures of three different protein toxins by X-ray crystallography has unexpectedly revealed a common membrane-insertion domain. This domain consists of an alpha-helical bundle of between seven and ten helices, some of which are hydrophobic. The three toxins, colicin, insecticidal delta-endotoxin and diphtheria toxin are directed towards different hosts, have different killing mechanisms and bear no sequence homology. The observation of a common membrane-insertion domain has implications for the design of therapeutic agents in combating disease.

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收藏

页码：391 / 395

页数：5

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