LIPOPROTEIN(A) AND ACCELERATED CORONARY-ARTERY DISEASE IN CARDIAC TRANSPLANT RECIPIENTS

被引:77
作者
BARBIR, M
KUSHWAHA, S
HUNT, B
MACKEN, A
THOMPSON, GR
MITCHELL, A
ROBINSON, D
YACOUB, M [1 ]
机构
[1] HAREFIELD HOSP,THORAC & CARDIAC SURG UNIT,UXBRIDGE UB9 6JH,MIDDX,ENGLAND
[2] HAMMERSMITH HOSP,MRC LIPOPROT TEAM,LONDON W12 0HS,ENGLAND
[3] UNIV SUSSEX,SCH MATH & PHYS SCI,BRIGHTON BN1 9RH,E SUSSEX,ENGLAND
关键词
D O I
10.1016/0140-6736(92)92756-6
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
High concentrations of serum lipoprotein(a) (Lp(a)) are associated with an increased risk of atherosclerotic vascular disease in the non-transplanted population. However its relation with accelerated coronary artery disease (CAD) in cardiac transplant recipients has not been reported. We measured serum Lp(a) in 130 cardiac transplant recipients undergoing routine follow-up, which included annual coronary angiography. The median Lp (a) concentration in 33 patients with CAD was 71 mg/dl, which was significantly higher than the corresponding value of 22 mg/dL in the 97 patients without CAD (p = 0.0006). Multivariant analysis showed the serum Lp(a) value to be a higher significant risk factor for CAD irrespective of the other factors included in the regression analysis. Thus a high concentration of serum Lp(a) is an important, independent risk factor for the development of accelerated CAD in transplant recipients.
引用
收藏
页码:1500 / 1502
页数:3
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