PROTEIN FOLDING IN THE CELL

被引：3795

作者：

GETHING, MJ ^{[1
]}

SAMBROOK, J ^{[1
]}

机构：

[1] HOWARD HUGHES MED INST, DALLAS, TX USA

来源：

NATURE | 1992年 / 355卷 / 6355期

关键词：

D O I：

10.1038/355033a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In the cell, as in vitro, the final conformation of a protein is determined by its amino-acid sequence. But whereas some isolated proteins can be denatured and refolded in vitro in the absence of other macromolecular cellular components, folding and assembly of polypeptides in vivo involves other proteins, many of which belong to families that have been highly conserved during evolution.

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页码：33 / 45

页数：13

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