SCNN1, AN EPITHELIAL-CELL SODIUM-CHANNEL GENE IN THE CONSERVED LINKAGE GROUP ON MOUSE CHROMOSOME-6 AND HUMAN-CHROMOSOME-12

被引：18

作者：

MEISLER, MH ^{[1
]}

BARROW, LL ^{[1
]}

CANESSA, CM ^{[1
]}

ROSSIER, BC ^{[1
]}

机构：

[1] UNIV LAUSANNE, INST PHARMACOL & TOXICOL, CH-1005 LAUSANNE, SWITZERLAND

来源：

GENOMICS | 1994年 / 24卷 / 01期

关键词：

D O I：

10.1006/geno.1994.1599

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

SCNN1, a gene encoding a nonvoltage-gated sodium channel, was detected using a rat colon cDNA probe with homology to Caenorhabditis elegans degenerin genes. Human SCNN1 was assigned to chromosome 12 using the NIGMS hybrid mapping panel 2. Mouse SCNN1 was mapped to a conserved linkage group on distal chromosome 6. The observed order of mouse genes was centromere-Raf1-(2.1 +/- 2.1)-Scnn1, Vwf-(1.9 +/- 1.9)-Ntf3, with 0/101 recombinants between Scnn1 and Vwf. No rearrangements of genomic DNA were detected in the linked mouse mutations deaf waddler (dfw) and opisthotonus (opt). (C) 1994 Academic Press, Inc.

引用

页码：185 / 186

页数：2

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