CASTRATION ENHANCES EXPRESSION OF GLIAL FIBRILLARY ACIDIC PROTEIN AND SULFATED GLYCOPROTEIN-2 IN THE INTACT AND LESION-ALTERED HIPPOCAMPUS OF THE ADULT MALE-RAT

被引：110

作者：

DAY, JR ^{[1
]}

LAPING, NJ ^{[1
]}

MCNEILL, TH ^{[1
]}

SCHREIBER, SS ^{[1
]}

PASINETTI, G ^{[1
]}

FINCH, CE ^{[1
]}

机构：

[1] UNIV SO CALIF,DEPT BIOL SCI,LOS ANGELES,CA 90089

来源：

MOLECULAR ENDOCRINOLOGY | 1990年 / 4卷 / 12期

关键词：

D O I：

10.1210/mend-4-12-1995

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This study concerns effects of the testes on two macromolecules in the rat hippocampus that were previously not known to be responsive to this endocrine axis. Castration for 3 weeks elevated the expression of glial fibrillary acidic protein (GFAP) and sulfated glycoprotein-2 (SGP-2) in male rat hippocampus, as shown by Northern blots and immunocytochemistry. SGP-2 mRNA was colocalized with GFAP, implying increased prevalence in astrocytes after castration. During hippocampal responses to deafferentation by entorhinal cortex lesions that damage the perforant path and induce synaptic reorganization, both mRNA and protein for SGP-2 and GFAP increase. Moreover, prior castration had an additive effect with entorhinal cortex lesions in the increase in GFAP and SGP-2 mRNA. These data suggest that testicular hormones regulate hippocampal astrocyte activity in intact adult rats as well as during synaptic reorganization in response to deafferenting lesions. (Molecular Endocrinology 4: 1995-2002, 1990)

引用

页码：1995 / 2002

页数：8

共 45 条

[1] GONADAL-STEROID INDUCTION OF STRUCTURAL SEX-DIFFERENCES IN THE CENTRAL NERVOUS-SYSTEM [J].