SYNTHESIS OF AN ENDOGENEOUS LECTIN, GALECTIN-1, BY HUMAN ENDOTHELIAL-CELLS IS UP-REGULATED BY ENDOTHELIAL-CELL ACTIVATION

被引：112

作者：

BAUM, LG ^{[1
]}

SEILHAMER, JJ ^{[1
]}

PANG, M ^{[1
]}

LEVINE, WB ^{[1
]}

BEYNON, D ^{[1
]}

BERLINER, JA ^{[1
]}

机构：

[1] INCYTE PHARMACEUT,PALO ALTO,CA 94304

来源：

GLYCOCONJUGATE JOURNAL | 1995年 / 12卷 / 01期

关键词：

LECTIN; GALECTIN-1; ENDOTHELIAL CELLS; HIGH ENDOTHELIAL VENULES; LYMPH NODE;

D O I：

10.1007/BF00731870

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The pattern of expression of an endogenous lectin, galectin-1, was examined in human lymphoid tissue. Galectin-1 was detected in the endothelial cells lining specialized vessels, termed high endothelial venules, in activated lymphoid tissue, but not in a resting lymph node. Cultured endothelial cells (human aortic and umbilical vein endothelial cells (HAECs and HUVECs)) expressed galectin-1. Activation of the cultured endothelial cells increased the level of galectin-1 expression, as determined by ELISA, Northern blot analysis and high throughput cDNA sequencing. These results suggest that galectin-1 expressed by endothelial cells may bind to and affect the trafficking of cells emigrating from blood into tissues.

引用

页码：63 / 68

页数：6

共 35 条

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