TRANSCRIPTIONAL REGULATION OF THE HUMAN INTERCELLULAR-ADHESION MOLECULE-1 GENE - A SHORT OVERVIEW

被引：61

作者：

STRATOWA, C

AUDETTE, M

机构：

[1] CHU LAVAL,RES CTR,MOLEC ENDOCRINOL LAB,LAVAL,PQ,CANADA

[2] UNIV LAVAL,LAVAL,PQ,CANADA

来源：

IMMUNOBIOLOGY | 1995年 / 193卷 / 2-4期

关键词：

D O I：

10.1016/S0171-2985(11)80558-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Human intercellular adhesion molecule-1 (ICAM-1), a transmembrane glycoprotein that functions as a ligand for lymphocyte function-associated antigen-1, plays an important role in mediating cell-cell interactions in inflammatory reactions. It is induced by proinflammatory cytokines such as interleukin 1, tumor necrosis factor-alpha or interferon-gamma, as well as by phorbol esters, retinoic acid and lipopolysaccharide. Furthermore, ICAM-1 is upregulated by interleukin-6, which suggests that it belongs to the family of acute phase response genes. Investigation of the 5'-regulatory region of the human ICAM-1 gene revealed sequence motifs for a variety of transcription factors implicated in transcriptional regulation. This review summarizes the current knowledge of the transcriptional regulation of the human ICAM-1 gene.

引用

页码：293 / 304

页数：12

共 37 条

[1] A NUCLEAR FACTOR FOR IL-6 EXPRESSION (NF-IL6) IS A MEMBER OF A C/EBP FAMILY [J].