INTERLEUKIN-10

被引：371

作者：

MALEFYT, RD

YSSEL, H

RONCAROLO, MG

SPITS, H

DEVRIES, JE

机构：

[1] DNAX Research Institute, Palo Alto, CA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1992年 / 4卷 / 03期

关键词：

D O I：

10.1016/0952-7915(92)90082-P

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Despite the short history of interleukin-10, accumulated evidence indicates that this interleukin plays a major role in suppressing immune and inflammatory responses. Yet interleukin-10 also maintains cell viability and acts as a cofactor to promote the growth of lymphoid and myeloid cells in vitro. Here we review the present knowledge on the structure and function of interleukin-10.

引用

收藏

页码：314 / 320

页数：7

相关论文

共 27 条

[1] MACROPHAGE DEACTIVATION BY INTERLEUKIN-10 [J].

BOGDAN, C ;

VODOVOTZ, Y ;

NATHAN, C .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 174 (06) :1549-1555

[2]

CHEN WF, 1991, J IMMUNOL, V147, P528

[3] 2 TYPES OF MOUSE HELPER T-CELL CLONE .3. FURTHER DIFFERENCES IN LYMPHOKINE SYNTHESIS BETWEEN TH1 AND TH2 CLONES REVEALED BY RNA HYBRIDIZATION, FUNCTIONALLY MONOSPECIFIC BIOASSAYS, AND MONOCLONAL-ANTIBODIES [J].

CHERWINSKI, HM ;

SCHUMACHER, JH ;

BROWN, KD ;

MOSMANN, TR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1987, 166 (05) :1229-1244

[4] 2 TYPES OF MOUSE T-HELPER CELL .4. TH2 CLONES SECRETE A FACTOR THAT INHIBITS CYTOKINE PRODUCTION BY TH1 CLONES [J].

FIORENTINO, DF ;

BOND, MW ;

MOSMANN, TR .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (06) :2081-2095

[5]

FIORENTINO DF, 1991, J IMMUNOL, V147, P3815

[6]

FIORENTINO DF, 1991, J IMMUNOL, V146, P3444

[7]

GAJEWSKI TF, 1988, J IMMUNOL, V140, P4245

[8]

GAZZINELLI RT, 1992, J IMMUNOL, V148, P1792

[9] INTERLEUKIN-10, A NOVEL B-CELL STIMULATORY FACTOR - UNRESPONSIVENESS OF X-CHROMOSOME LINKED IMMUNODEFICIENCY-B CELLS [J].

GO, NF ;

CASTLE, BE ;

BARRETT, R ;

KASTELEIN, R ;

DANG, W ;

MOSMANN, TR ;

MOORE, KW ;

HOWARD, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 172 (06) :1625-1631

[10] EXPRESSION OF INTERLEUKIN-10 ACTIVITY BY EPSTEIN-BARR-VIRUS PROTEIN BCRF1 [J].

HSU, DH ;

MALEFYT, RD ;

FIORENTINO, DF ;

DANG, MN ;

VIEIRA, P ;

DEVRIES, J ;

SPITS, H ;

MOSMANN, TR ;

MOORE, KW .

SCIENCE, 1990, 250 (4982) :830-832