AMITRIPTYLINE METABOLITES - SYNTHESIS OF (R,S)-(Z)- AND (R,S)-(E)- N-METHYL(10,11-DIHYDRO-10-HYDROXY-5H-DIBENZO[A,D]CYCLOHEPTENE)-DELTA-5GAMMA-PROPYLAMINE

被引：7

作者：

REMY, DC ^{[1
]}

VANSAUN, WA ^{[1
]}

ENGELHAR.EL ^{[1
]}

机构：

[1] MERCK SHARP & DOHME RES LABS,W POINT,PA 19486

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1973年 / 38卷 / 04期

关键词：

D O I：

10.1021/jo00944a018

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

引用

页码：700 / 703

页数：4

共 14 条

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BERTILSSON, L ;

ALEXANDERSON, B .

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 1972, 4 (04) :201-+

[2] IDENTIFICATION OF A MAJOR METABOLITE OF NORTRIPTYLINE IN HUMAN URINE [J].

DELEENHEER, A ;

HEYNDRICKX, A .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1971, 60 (09) :1403-+

[3] PARAMAGNETIC SHIFTS IN SOLUTIONS OF CHOLESTEROL AND DIPYRIDINE ADDUCT OF TRISDIPIVALOMETHANATOEUROPIUM(3) . A SHIFT REAGENT [J].

HINCKLEY, CC .

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[4]

HUCKER H. B., 1961, FED PROC, V20, P172

[5]

HUCKER HB, 1962, PHARMACOLOGIST, V4, P171

[6] METABOLISM OF NORTRIPTYLINE-N-METHYL-14C IN RATS [J].

MCMAHON, RE ;

MARSHALL, FJ ;

CULP, W ;

MILLER, WM .

BIOCHEMICAL PHARMACOLOGY, 1963, 12 (10) :1207-&

[7]

MUNKSGAARD EC, 1969, ACTA PHARMACOL TOX, V27, P129

[8] NEUROTROPIC AND PSYCHOTROPIC COMPOUNDS .33. CONTRIBUTION TO CHEMISTRY OF 11-(3-DIMETHYLAMINOPROPYLIDENE)-6,11-DIHYDRODIBENZO[B,E]-THIEPIN (PROTHIADENE) AND OF RELATED COMPOUNDS [J].

RAJSNER, M ;

SVATEK, E ;

METYSOVA, J ;

PROTIVA, M .

COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS, 1969, 34 (07) :1963-&

[9]

REMY DC, 1971, TETRAHEDRON LETT, P2463

[10]

RONDEAU RE, 1971, J AM CHEM SOC, V93, P1522

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