DETERMINANT SPREADING AND THE DYNAMICS OF THE AUTOIMMUNE T-CELL REPERTOIRE

被引：444

作者：

LEHMANN, PV

SERCARZ, EE

FORSTHUBER, T

DAYAN, CM

GAMMON, G

机构：

[1] XENOVA LTD,SLOUGH SL1 4EQ,ENGLAND

[2] CHARING CROSS HOSP,DEPT ENDOCRINOL,LONDON W6,ENGLAND

[3] UNIV CALIF LOS ANGELES,DEPT MICROBIOL & MOLEC GENET,LOS ANGELES,CA 90024

来源：

IMMUNOLOGY TODAY | 1993年 / 14卷 / 05期

关键词：

D O I：

10.1016/0167-5699(93)90163-F

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In this article the authors propose a dynamic model of autoimmunity with T-cell recruitment and selection leading to changes in the specificity of the anti-self response during the course of disease. They argue that these changes are due to alterations in self-antigen presentation that lead to the display of previously cryptic self-determinants. Mechanisms that could underlie this differential self-presentation are proposed.

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页码：203 / 208

页数：6

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