ALZHEIMER-DISEASE - MEASURING LOSS OF CEREBRAL GRAY-MATTER WITH MR IMAGING

被引：197

作者：

RUSINEK, H ^{[1
]}

DELEON, MJ ^{[1
]}

GEORGE, AE ^{[1
]}

STYLOPOULOS, LA ^{[1
]}

CHANDRA, R ^{[1
]}

SMITH, G ^{[1
]}

RAND, T ^{[1
]}

MOURINO, M ^{[1
]}

KOWALSKI, H ^{[1
]}

机构：

[1] NYU MED CTR, DEPT PSYCHIAT, NEW YORK, NY 10016 USA

来源：

RADIOLOGY | 1991年 / 178卷 / 01期

关键词：

BRAIN; ATROPHY; MR STUDIES; DEMENTIA; MAGNETIC RESONANCE (MR); IMAGE PROCESSING; TISSUE CHARACTERIZATION;

D O I：

10.1148/radiology.178.1.1984287

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The distributions of the cerebral gray matter, the white matter, and the intracranial cerebrospinal fluid (CSF) were measured in 14 patients with Alzheimer disease (AD) and in 14 healthy control subjects. The measurements, derived from two specifically designed magnetic resonance inversion-recovery sequences, compensate for partial signal averaging. The percentage of the gray matter in the brains of AD patients (44.9% +/- 4.4) was significant lower than in control subjects (50.2% +/- 3.2). The most significant reduction (P < .001) occurred in the temporal lobes (13.8%) and a central region (12.8%); the reduction in frontal lobe (11.2%) and occipital lobe (9.2%) was also statistically significant (P < .01). There was an increase in the CSF volume in the temporal, occipital, and frontal regions; no region showed a significant difference in the white matter content. The findings of diffuse changes and temporal lobe involvement in AD are consistent with pathologic observations of cortical cell loss.

引用

页码：109 / 114

页数：6

共 29 条

[1] ALZHEIMERS-DISEASE - AREAL AND LAMINAR PATHOLOGY IN THE OCCIPITAL ISOCORTEX [J].