MUCOCUTANEOUS ERUPTIONS DUE TO ANTIEPILEPTIC DRUG-THERAPY IN CHILDREN

被引：29

作者：

POLLACK, MA

BURK, PG

NATHANSON, G

机构：

[1] MONTEFIORE HOSP & MED CTR,ALBERT EINSTEIN COLL MED,DEPT PEDIAT,BRONX,NY 10467

[2] MONTEFIORE HOSP & MED CTR,ALBERT EINSTEIN COLL MED,DEPT DERMATOL,BRONX,NY 10467

来源：

ANNALS OF NEUROLOGY | 1979年 / 5卷 / 03期

关键词：

D O I：

10.1002/ana.410050308

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Three children with bullous erythema multiforme and 1 with toxic epidermal necrolysis associated with antiepileptic drug therapy are described. One patient is unique because of seven mucocutaneous eruptions caused by three classes of antiepileptic drugs. Lymphocyte stimulation by antiepileptic drugs could not be demonstrated in the 2 patients in whom appropriate studies were performed, and no precipitating antibodies to antiepileptic drugs were found. Observation of four diagnostic and therapeutic principles, which are illustrated by the course of our patients, may reduce the incidence of life‐threatening mucocutaneous eruptions and simplify the long‐term management of individuals in whom such reactions occur. Copyright © 1979 American Neurological Association

引用

页码：262 / 267

页数：6

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