A NOVEL METALLOPROTEASE DISINTEGRIN-LIKE GENE AT 17Q21.3 IS SOMATICALLY REARRANGED IN 2 PRIMARY BREAST CANCERS

被引：100

作者：

EMI, M

KATAGIRI, T

HARADA, Y

SAITO, H

INAZAWA, J

ITO, I

KASUMI, F

NAKAMURA, Y

机构：

[1] JAPANESE FDN CANC RES,INST CANC,DEPT BIOCHEM,1-37-1 KAMI KEBUKURO,TOSHIMA KU,TOKYO 170,JAPAN

[2] JAPANESE FDN CANC RES,INST CANC,DEPT SURG,TOKYO 170,JAPAN

来源：

NATURE GENETICS | 1993年 / 5卷 / 02期

关键词：

D O I：

10.1038/ng1093-151

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

From chromosomal region 17q21.3, where a tumour suppressor gene(s) for breast and ovarian cancers is thought to be present, we have isolated a novel gene from a cosmid clone that revealed somatic rearrangements in two breast cancers. The gene (MDC) encodes a 524-amino acid metalloprotease-like, disintegrin-like and cysteine-rich protein with sequence similarity to members of the snake-venom metalloprotease/disintegrin family and guinea-pig sperm-surface protein PH-30. These proteins have been implicated in cell-cell or cell-extracellular matrix interactions. Rearrangements in both tumours involve multiple exons and disrupt the coding region of the new MDC.

引用

页码：151 / 157

页数：7

共 30 条

[1] A COMMON PRECURSOR FOR A PUTATIVE HEMORRHAGIC PROTEIN AND RHODOSTOMIN, A PLATELET-AGGREGATION INHIBITOR OF THE VENOM OF CALLOSELASMA-RHODOSTOMA - MOLECULAR-CLONING AND SEQUENCE-ANALYSIS [J].