PURIFICATION AND CHARACTERIZATION OF PROSTAGLANDIN ENDOPEROXIDE D-ISOMERASE, A CYTOPLASMIC, GLUTATHIONE-REQUIRING ENZYME

被引：149

作者：

CHRISTHAZELHOF, E

NUGTEREN, DH

机构：

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 572卷 / 01期

关键词：

Endoperoxide D-isomerase; Glutathione; Prostaglandin isomerase;

D O I：

10.1016/0005-2760(79)90198-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Prostaglandin endoperoxide D-isomerase in rat spleen was purified until homogeneity. This cytoplasmic enzyme occurs in many organs of the rat and also in other species and requires specifically glutathione for its action. The molecular weight is 30 000 and the isoelectric point pI 5.2. © 1979.

引用

收藏

页码：43 / 51

页数：9

相关论文

共 15 条

[1] IDENTIFICATION OF PROSTAGLANDIN D2 AS A MAJOR PROSTAGLANDIN IN HOMOGENATES OF RAT-BRAIN [J].

ABDELHALIM, MS ;

HAMBERG, M ;

SJOQUIST, B ;

ANGGARD, E .

PROSTAGLANDINS, 1977, 14 (04) :633-643

[2] CONVERSIONS OF PROSTAGLANDIN ENDOPEROXIDES BY GLUTATHIONE-S-TRANSFERASES AND SERUM ALBUMINS [J].

CHRISTHAZELHOF, E ;

NUGTEREN, DH ;

VANDORP, DA .

BIOCHIMICA ET BIOPHYSICA ACTA, 1976, 450 (03) :450-461

[3] BIOSYNTHESIS AND CHEMISTRY OF 9 ALPHA,15(S)-DIHYDROXY-11-OXO-13-TRANS-PROSTENOIC ACID [J].

FOSS, PS ;

TAKEGUCHI, C ;

SIH, CJ ;

SCHNOES, H .

BIOCHEMISTRY, 1972, 11 (12) :2271-+

[4]

GRANSTROM E, 1968, J BIOL CHEM, V243, P4104

[5] PROSTAGLANDIN ENDOPEROXIDES .4. EFFECTS ON SMOOTH-MUSCLE [J].

HAMBERG, M ;

HEDQVIST, P ;

STRANDBERG, K ;

SVENSSON, J ;

SAMUELSSON, B .

LIFE SCIENCES, 1975, 16 (03) :451-462

[6] CHEMICAL-STRUCTURE OF PROSTAGLANDIN-X (PROSTACYCLIN) [J].

JOHNSON, RA ;

MORTON, DR ;

KINNER, JH ;

GORMAN, RR ;

MCGUIRE, JC ;

SUN, FF ;

WHITTAKER, N ;

BUNTING, S ;

SALMON, J ;

MONCADA, S ;

VANE, JR .

PROSTAGLANDINS, 1976, 12 (06) :915-928

[7]

MIYAMOTO T, 1976, J BIOL CHEM, V251, P2629

[8] IDENTIFICATION OF AN ENZYME IN PLATELET MICROSOMES WHICH GENERATES THROMBOXANE-A-2 FROM PROSTAGLANDIN ENDOPEROXIDES [J].

NEEDLEMAN, P ;

MONCADA, S ;

BUNTING, S ;

VANE, JR ;

HAMBERG, M ;

SAMUELSSON, B .

NATURE, 1976, 261 (5561) :558-560

[9] ISOLATION AND PROPERTIES OF INTERMEDIATES IN PROSTAGLANDIN BIOSYNTHESIS [J].

NUGTEREN, DH ;

HAZELHOF, E .

BIOCHIMICA ET BIOPHYSICA ACTA, 1973, 326 (03) :448-461

[10]

NUGTEREN DH, 1966, RECL TRAV CHIM PAY-B, V85, P405