OXIDIZED HDL ARE MUCH LESS CYTOTOXIC TO LYMPHOBLASTOID-CELLS THAN OXIDIZED LDL

被引：16

作者：

ALOMAR, Y ^{[1
]}

NEGRESALVAYRE, A ^{[1
]}

LEVADE, T ^{[1
]}

VALDIGUIE, P ^{[1
]}

SALVAYRE, R ^{[1
]}

机构：

[1] UNIV TOULOUSE 3,FAC MED,BIOCHIM LAB,F-31062 TOULOUSE,FRANCE

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1128卷 / 2-3期

关键词：

LIPOPROTEIN; HDL; OXIDIZED LIPOPROTEIN; APOLIPOPROTEIN A-I; ULTRAVIOLET; PEROXIDATION; CYTOTOXICITY; (LYMPHOBLASTOID CELLS);

D O I：

10.1016/0005-2760(92)90302-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The possible effect of oxidized HDL was investigated on lymphoblastoid cells, in comparison to the cytotoxic effect of oxidized LDL. Oxidation of HDL was promoted by UV-C irradiation, or by copper ion (5 muM) or the combination of the two treatments. HDL extensively treated by UV-C for 20 h did not exhibit any cytotoxic effect on cultured lymphoblastoid cells even at a concentration of 500 mug apolipoprotein A-I/ml. In contrast to UV-treated (2 h) LDL, which were highly cytotoxic (already at a concentration of 100 mug apolipoprotein B/ml), HDL treated by copper or copper + UV were oxidized, as shown by TBARS formation and PUFA content decrease, but were slightly cytotoxic.

引用

页码：163 / 166

页数：4

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