CONFORMATION AND MOLECULAR-BIOLOGY OF POLYPEPTIDE HORMONES .2. GLUCAGON

被引：11

作者：

BLUNDELL, T

机构：

[1] Tom Blundell is at the Laboratory of Molecular Biology, Department of Crystallography, Birkbeck College, London WCIE 7HX, Malet Street

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1979年 / 4卷 / 04期

关键词：

D O I：

10.1016/0968-0004(79)90187-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Monomeric glucagon has an extended flexible structure. Self-association to trimers and higher oligomers is accompanied by the formation of helix. It is probable that a helical conformer is also stabilized when glucagon binds its membrane receptor. © 1979.

引用

页码：80 / 83

页数：4

共 25 条

[1] FORMATION AND STRUCTURE OF GELS AND FIBRILS FROM GLUCAGON [J].

BEAVEN, GH ;

GRATZER, WB ;

DAVIES, HG .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1969, 11 (01) :37-&

[2] BIOCHEMISTRY OF THE PROTEIN HORMONES [J].

BEHRENS, OK ;

BROMER, WW .

ANNUAL REVIEW OF BIOCHEMISTRY, 1958, 27 :57-100

[3] EVIDENCE OF ASSOCIATION OF GLUCAGON FROM OPTICAL ROTATORY DISPERSION AND CONCENTRATION-DIFFERENCE SPECTRA [J].

BLANCHARD, MH ;

KING, MV .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1966, 25 (03) :298-+

[4] RELATION OF STRUCTURE TO STORAGE AND RECEPTOR-BINDING OF GLUCAGON [J].

BLUNDELL, TL ;

DOCKERILL, S ;

SASAKI, K ;

TICKLE, IJ ;

WOOD, SP .

METABOLISM-CLINICAL AND EXPERIMENTAL, 1976, 25 (11) :1331-1339

[5] HISTOCHEMICAL AND ULTRASTRUCTURAL STUDIES ON PANCREATIC A-CELLS - EVIDENCE FOR GLUCAGON AND NON-GLUCAGON COMPONENTS OF ALPHA GRANULE [J].

BUSSOLATI, G ;

CAPELLA, C ;

VASSALLO, G ;

SOLCIA, E .

DIABETOLOGIA, 1971, 7 (03) :181-+

[6] CONFORMATION OF GLUCAGON - PREDICTIONS AND CONSEQUENCES [J].

CHOU, PY ;

FASMAN, GD .

BIOCHEMISTRY, 1975, 14 (11) :2536-2541

[7] STUDY OF CONFORMATIONAL PROPERTIES OF GLUCAGON IN PRESENCE OF GLYCOLS [J].

CONTAXIS, CC ;

EPAND, RM .

CANADIAN JOURNAL OF BIOCHEMISTRY, 1974, 52 (06) :456-468

[8]

EDELHOCH H, 1969, J BIOL CHEM, V244, P3876

[9] INTERACTION OF GLUCAGON WITH DIMYRISTOYL GLYCEROPHOSPHOCHOLINE [J].

EPAND, RM ;

JONES, AJS ;

SCHREIER, S .

BIOCHIMICA ET BIOPHYSICA ACTA, 1977, 491 (01) :296-304

[10] THERMODYNAMICS OF SELF-ASSOCIATION OF GLUCAGON [J].

FORMISANO, S ;

JOHNSON, ML ;

EDELHOCH, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (08) :3340-3344

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