INTERACTION OF P107 WITH CYCLIN-A INDEPENDENT OF COMPLEX-FORMATION WITH VIRAL ONCOPROTEINS

被引：222

作者：

EWEN, ME ^{[1
]}

FAHA, B ^{[1
]}

HARLOW, E ^{[1
]}

LIVINGSTON, DM ^{[1
]}

机构：

[1] MASSACHUSETTS GEN HOSP,CTR CANC,BOSTON,MA 02129

来源：

SCIENCE | 1992年 / 255卷 / 5040期

关键词：

D O I：

10.1126/science.1532457

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The p107 protein and the retinoblastoma protein (R-B) both bind specifically to two viral oncoproteins, the SV40 T antigen (T) and adenoviral protein E1A (E1A). Like RB, p107 contains a segment (the pocket) that, alone, can bind specifically to T, EIA, and multiple cellular proteins. Cyclin A bound to the p107 pocket, but not the R-B pocket. Although both pockets contain two, related collinear subsegments (A and B), the unique sequence in the p107 pocket that occupies the space between A and B is required for the interaction with cyclin A.

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页码：85 / 87

页数：3

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