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TETRAHYDROBIOPTERIN-DEPENDENT PRODUCTION OF L-DOPA IN NRK FIBROBLASTS TRANSFECTED WITH TYROSINE-HYDROXYLASE CDNA - FUTURE USE FOR INTRACEREBRAL GRAFTING
被引:24
作者
:
UCHIDA, K
论文数:
0
引用数:
0
h-index:
0
机构:
NATL INST NEUROSCI,DEPT NEUROCHEM,4-1-1 OGAWA HIGASHI,KODAIRA,TOKYO 187,JAPAN
UCHIDA, K
ISHII, A
论文数:
0
引用数:
0
h-index:
0
机构:
NATL INST NEUROSCI,DEPT NEUROCHEM,4-1-1 OGAWA HIGASHI,KODAIRA,TOKYO 187,JAPAN
ISHII, A
KANEDA, N
论文数:
0
引用数:
0
h-index:
0
机构:
NATL INST NEUROSCI,DEPT NEUROCHEM,4-1-1 OGAWA HIGASHI,KODAIRA,TOKYO 187,JAPAN
KANEDA, N
TOYA, S
论文数:
0
引用数:
0
h-index:
0
机构:
NATL INST NEUROSCI,DEPT NEUROCHEM,4-1-1 OGAWA HIGASHI,KODAIRA,TOKYO 187,JAPAN
TOYA, S
NAGATSU, T
论文数:
0
引用数:
0
h-index:
0
机构:
NATL INST NEUROSCI,DEPT NEUROCHEM,4-1-1 OGAWA HIGASHI,KODAIRA,TOKYO 187,JAPAN
NAGATSU, T
KOHSAKA, S
论文数:
0
引用数:
0
h-index:
0
机构:
NATL INST NEUROSCI,DEPT NEUROCHEM,4-1-1 OGAWA HIGASHI,KODAIRA,TOKYO 187,JAPAN
KOHSAKA, S
机构
:
[1]
NATL INST NEUROSCI,DEPT NEUROCHEM,4-1-1 OGAWA HIGASHI,KODAIRA,TOKYO 187,JAPAN
[2]
KEIO UNIV,SCH MED,DEPT NEUROSURG,TOKYO 108,JAPAN
[3]
NAGOYA UNIV,SCH MED,DEPT BIOCHEM,NAGOYA,AICHI 466,JAPAN
来源
:
NEUROSCIENCE LETTERS
|
1990年
/ 109卷
/ 03期
关键词
:
(6R)-l-Erythro-tetrahydrobiopterin;
Intracerebral grafting;
l-3,4-Dihydroxyphenylalanine;
NRK fibroblast;
Tyrosine hydroxylase;
Tyrosine hydroxylase cDNA;
D O I
:
10.1016/0304-3940(90)90008-W
中图分类号
:
Q189 [神经科学];
学科分类号
:
071006 ;
摘要
:
In the present study, tyrosine hydroxylase (TH; EC 1.14.16.2) cDNA was transfected into cultured fibroblasts and the production of l-3,4-dihydroxyphenylalanine (l-DOPA) was determined. Type 2 TH cDNA was transfected into fibroblasts (NRK-49F) derived from the normal rat kidney, and the expression of the TH minigene was screened by immunocytochemical staining and immunoblotting analysis with TH antiserum. Several clones of the NRK transfectants that produce TH molecules were obtained. The expressed TH molecules showed high enzyme activity in a complete assay system in vitro. However, l-DOPA was not detected in the cultured cells due to the possible absence of de novo synthesis of (6R)-l-erythro-tetrahydrobiopterin (BH4) in these cells. When BH4 was added to the medium, a large amount of l-DOPA was detected not only in the cells but also in the medium. These findings may aid in regulating the amount of l-DOPA secretion from cells after they are transplanted into the brain. © 1990.
引用
收藏
页码:282 / 286
页数:5
相关论文
共 12 条
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ERIKSSON, T
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2
→
共 12 条
[1]
NEURAL GRAFTING IN ANIMAL-MODELS OF NEURODEGENERATIVE DISEASES
[J].
BJORKLUND, A
论文数:
0
引用数:
0
h-index:
0
BJORKLUND, A
;
GAGE, FH
论文数:
0
引用数:
0
h-index:
0
GAGE, FH
.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES,
1985,
457
:53
-81
[2]
EPITHELIOID AND FIBROBLASTIC RAT-KIDNEY CELL CLONES - EPIDERMAL GROWTH-FACTOR (EGF) RECEPTORS AND EFFECT OF MOUSE SARCOMA-VIRUS TRANSFORMATION
[J].
DELARCO, JE
论文数:
0
引用数:
0
h-index:
0
DELARCO, JE
;
TODARO, GJ
论文数:
0
引用数:
0
h-index:
0
TODARO, GJ
.
JOURNAL OF CELLULAR PHYSIOLOGY,
1978,
94
(03)
:335
-342
[3]
ON-OFF PHENOMENON IN PARKINSONS-DISEASE - RELATIONSHIP BETWEEN DOPA AND OTHER LARGE NEUTRAL AMINO-ACIDS IN PLASMA
[J].
ERIKSSON, T
论文数:
0
引用数:
0
h-index:
0
机构:
GOTHENBURG UNIV,ORAL BIOL LAB,S-40033 GOTHENBURG,SWEDEN
ERIKSSON, T
;
GRANERUS, AK
论文数:
0
引用数:
0
h-index:
0
机构:
GOTHENBURG UNIV,ORAL BIOL LAB,S-40033 GOTHENBURG,SWEDEN
GRANERUS, AK
;
LINDE, A
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0
引用数:
0
h-index:
0
机构:
GOTHENBURG UNIV,ORAL BIOL LAB,S-40033 GOTHENBURG,SWEDEN
LINDE, A
;
CARLSSON, A
论文数:
0
引用数:
0
h-index:
0
机构:
GOTHENBURG UNIV,ORAL BIOL LAB,S-40033 GOTHENBURG,SWEDEN
CARLSSON, A
.
NEUROLOGY,
1988,
38
(08)
:1245
-1248
[4]
AUTO-TRANSPLANTATION OF THE SUPERIOR CERVICAL-GANGLION INTO THE BRAIN - A POSSIBLE THERAPY FOR PARKINSONS-DISEASE
[J].
ITAKURA, T
论文数:
0
引用数:
0
h-index:
0
ITAKURA, T
;
KAMEI, I
论文数:
0
引用数:
0
h-index:
0
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;
NAKAI, K
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0
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h-index:
0
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;
NAKA, Y
论文数:
0
引用数:
0
h-index:
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;
NAKAKITA, K
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0
引用数:
0
h-index:
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NAKAKITA, K
;
IMAI, H
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0
引用数:
0
h-index:
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IMAI, H
;
KOMAI, N
论文数:
0
引用数:
0
h-index:
0
KOMAI, N
.
JOURNAL OF NEUROSURGERY,
1988,
68
(06)
:955
-959
[5]
ISOLATION OF A NOVEL CDNA CLONE FOR HUMAN TYROSINE-HYDROXYLASE - ALTERNATIVE RNA SPLICING PRODUCES 4 KINDS OF MESSENGER-RNA FROM A SINGLE GENE
[J].
KANEDA, N
论文数:
0
引用数:
0
h-index:
0
机构:
NAGOYA UNIV,SCH MED,DEPT BIOCHEM,NAGOYA,AICHI 466,JAPAN
KANEDA, N
;
KOBAYASHI, K
论文数:
0
引用数:
0
h-index:
0
机构:
NAGOYA UNIV,SCH MED,DEPT BIOCHEM,NAGOYA,AICHI 466,JAPAN
KOBAYASHI, K
;
ICHINOSE, H
论文数:
0
引用数:
0
h-index:
0
机构:
NAGOYA UNIV,SCH MED,DEPT BIOCHEM,NAGOYA,AICHI 466,JAPAN
ICHINOSE, H
;
KISHI, F
论文数:
0
引用数:
0
h-index:
0
机构:
NAGOYA UNIV,SCH MED,DEPT BIOCHEM,NAGOYA,AICHI 466,JAPAN
KISHI, F
;
NAKAZAWA, A
论文数:
0
引用数:
0
h-index:
0
机构:
NAGOYA UNIV,SCH MED,DEPT BIOCHEM,NAGOYA,AICHI 466,JAPAN
NAKAZAWA, A
;
KUROSAWA, Y
论文数:
0
引用数:
0
h-index:
0
机构:
NAGOYA UNIV,SCH MED,DEPT BIOCHEM,NAGOYA,AICHI 466,JAPAN
KUROSAWA, Y
;
FUJITA, K
论文数:
0
引用数:
0
h-index:
0
机构:
NAGOYA UNIV,SCH MED,DEPT BIOCHEM,NAGOYA,AICHI 466,JAPAN
FUJITA, K
;
NAGATSU, T
论文数:
0
引用数:
0
h-index:
0
机构:
NAGOYA UNIV,SCH MED,DEPT BIOCHEM,NAGOYA,AICHI 466,JAPAN
NAGATSU, T
.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,
1987,
146
(03)
:971
-975
[6]
DRAMATIC RESULTS WITH BRAIN GRAFTS
[J].
LEWIN, R
论文数:
0
引用数:
0
h-index:
0
LEWIN, R
.
SCIENCE,
1987,
237
(4812)
:245
-247
[7]
EXPRESSION OF FUNCTIONAL ACETYLCHOLINE-RECEPTOR FROM CLONED CDNAS
[J].
MISHINA, M
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO UNIV,DEPT PHYSIOL,KYOTO 606,JAPAN
MISHINA, M
;
KUROSAKI, T
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO UNIV,DEPT PHYSIOL,KYOTO 606,JAPAN
KUROSAKI, T
;
TOBIMATSU, T
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO UNIV,DEPT PHYSIOL,KYOTO 606,JAPAN
TOBIMATSU, T
;
MORIMOTO, Y
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO UNIV,DEPT PHYSIOL,KYOTO 606,JAPAN
MORIMOTO, Y
;
NODA, M
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO UNIV,DEPT PHYSIOL,KYOTO 606,JAPAN
NODA, M
;
YAMAMOTO, T
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO UNIV,DEPT PHYSIOL,KYOTO 606,JAPAN
YAMAMOTO, T
;
TERAO, M
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO UNIV,DEPT PHYSIOL,KYOTO 606,JAPAN
TERAO, M
;
LINDSTROM, J
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO UNIV,DEPT PHYSIOL,KYOTO 606,JAPAN
LINDSTROM, J
;
TAKAHASHI, T
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO UNIV,DEPT PHYSIOL,KYOTO 606,JAPAN
TAKAHASHI, T
;
KUNO, M
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO UNIV,DEPT PHYSIOL,KYOTO 606,JAPAN
KUNO, M
;
NUMA, S
论文数:
0
引用数:
0
h-index:
0
机构:
KYOTO UNIV,DEPT PHYSIOL,KYOTO 606,JAPAN
NUMA, S
.
NATURE,
1984,
307
(5952)
:604
-608
[8]
BIOPTERIN COFACTOR AND MONOAMINE-SYNTHESIZING MONOOXYGENASES
[J].
NAGATSU, T
论文数:
0
引用数:
0
h-index:
0
NAGATSU, T
.
NEUROCHEMISTRY INTERNATIONAL,
1983,
5
(01)
:27
-38
[9]
NERVE-CELL GRAFTING IN PARKINSONS-DISEASE
[J].
SLADEK, JR
论文数:
0
引用数:
0
h-index:
0
SLADEK, JR
;
GASH, DM
论文数:
0
引用数:
0
h-index:
0
GASH, DM
.
JOURNAL OF NEUROSURGERY,
1988,
68
(03)
:337
-351
[10]
SOUTHERN P J, 1982, Journal of Molecular and Applied Genetics, V1, P327
←
1
2
→