ELEVATION OF VENTRICULAR DEFIBRILLATION THRESHOLD IN DOGS BY ANTI-ARRHYTHMIC DRUGS

被引:115
作者
BABBS, CF [1 ]
YIM, GKW [1 ]
WHISTLER, SJ [1 ]
TACKER, WA [1 ]
GEDDES, LA [1 ]
机构
[1] PURDUE UNIV,DEPT PHARMACOL & TOXICOL,W LAFAYETTE,IN 47907
关键词
D O I
10.1016/0002-8703(79)90047-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Effects of antiarrhythmic drugs upon the threshold delivered energy (TDE) and threshold peak current (TPC) for electrical ventricular defibrillation by damped sinusoidal shocks were investigated in 25 pentobarbital-anesthetized dogs. TDE and TPC were increased by the three antiarrhythmic drugs tested. Bolus injections produced a transient rise and continuous infusions produced a steady rise in defibrillation threshold. The maximal percent elevations in mean defibrillation threshold during the 60 minutes after intravenous drug treatment in groups of n = 5 dogs were: {A table is presented} Accordingly, individuals receiving antiarrhythmic drugs who nonetheless fibrillate may require greater electric shock strength for defibrillation. © 1979.
引用
收藏
页码:345 / 350
页数:6
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