ELEVATION OF VENTRICULAR DEFIBRILLATION THRESHOLD IN DOGS BY ANTI-ARRHYTHMIC DRUGS

被引：115

作者：

BABBS, CF ^{[1
]}

YIM, GKW ^{[1
]}

WHISTLER, SJ ^{[1
]}

TACKER, WA ^{[1
]}

GEDDES, LA ^{[1
]}

机构：

[1] PURDUE UNIV,DEPT PHARMACOL & TOXICOL,W LAFAYETTE,IN 47907

来源：

AMERICAN HEART JOURNAL | 1979年 / 98卷 / 03期

关键词：

D O I：

10.1016/0002-8703(79)90047-4

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Effects of antiarrhythmic drugs upon the threshold delivered energy (TDE) and threshold peak current (TPC) for electrical ventricular defibrillation by damped sinusoidal shocks were investigated in 25 pentobarbital-anesthetized dogs. TDE and TPC were increased by the three antiarrhythmic drugs tested. Bolus injections produced a transient rise and continuous infusions produced a steady rise in defibrillation threshold. The maximal percent elevations in mean defibrillation threshold during the 60 minutes after intravenous drug treatment in groups of n = 5 dogs were: {A table is presented} Accordingly, individuals receiving antiarrhythmic drugs who nonetheless fibrillate may require greater electric shock strength for defibrillation. © 1979.

引用

页码：345 / 350

页数：6

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