HYPOTHESIS ON A SPECIFIC SEQUENCE-DEPENDENT CONFORMATION OF DNA AND ITS RELATION TO THE BINDING OF THE LAC-REPRESSOR PROTEIN

被引：394

作者：

KLUG, A

JACK, A

VISWAMITRA, MA

KENNARD, O

SHAKKED, Z

STEITZ, TA

机构：

[1] INDIAN INST SCI,DEPT PHYS,BANGALORE 560012,INDIA

[2] INDIAN INST SCI,GENET & CELL BIOL UNIT,BANGALORE 560012,INDIA

[3] UNIV CAMBRIDGE,CHEM LAB,CAMBRIDGE,ENGLAND

[4] YALE UNIV,DEPT MOLEC BIOPHYS & BIOCHEM,NEW HAVEN,CT 06520

来源：

JOURNAL OF MOLECULAR BIOLOGY | 1979年 / 131卷 / 04期

关键词：

D O I：

10.1016/0022-2836(79)90196-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure and properties of the double-helical form of the alternating copolymer poly(dA-dT) are considered. Different lines of evidence are interpreted in terms of a structure in which every second phosphate-diester linkage has a conformation different from that of the normal B form. A rationale for this alternating-B" structure is given which provides an explanation for the effects of chemical modifications of the T residues on the binding of the poly(dA-dT)· poly(dA-dT) to the lac repressor of Escherichia coli. © 1979."

引用

页码：669 / 680

页数：12

共 30 条

[1] REFINEMENT OF STRUCTURE OF B-DNA AND IMPLICATIONS FOR ANALYSIS OF X-RAY-DIFFRACTION DATA FROM FIBERS OF BIOPOLYMERS [J].