KNOWLEDGE-BASED PREDICTION OF PROTEIN STRUCTURES AND THE DESIGN OF NOVEL MOLECULES

被引：577

作者：

BLUNDELL, TL

SIBANDA, BL

STERNBERG, MJE

THORNTON, JM

机构：

[1] Laboratory of Molecular Biology, Department of Crystallography, Birbeck College, University of London, London WC1E 7HX, United Kingdom

来源：

NATURE | 1987年 / 326卷 / 6111期

关键词：

BIOCHEMISTRY - DNA Sequences - BIOLOGICAL MATERIALS - DNA - DATABASE SYSTEMS - PROTEINS - Synthesis;

D O I：

10.1038/326347a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Prediction of the tertiary structures of proteins may be carried out using a knowledge-based approach. This depends on identification of analogies in secondary structures, motifs, domains or ligand interactions between a protein to be modelled and those of known three-dimensional structures. Such techniques are of value in prediction of receptor structures to aid the design of drugs, herbicides or pesticides, antigens in vaccine design, and novel molecules in protein engineering.

引用

页码：347 / 352

页数：6

共 74 条

[1] STRUCTURE OF SOUTHERN BEAN MOSAIC-VIRUS AT 2.8-A RESOLUTION [J].

ABADZAPATERO, C ;

ABDELMEGUID, SS ;

JOHNSON, JE ;

LESLIE, AGW ;

RAYMENT, I ;

ROSSMANN, MG ;

SUCK, D ;

TSUKIHARA, T .

NATURE, 1980, 286 (5768) :33-39

[2] 3-DIMENSIONAL STRUCTURE OF HUMAN RENIN [J].

AKAHANE, K ;

UMEYAMA, H ;

NAKAGAWA, S ;

MORIGUCHI, I ;

HIROSE, S ;

IIZUKA, K ;

MURAKAMI, K .

HYPERTENSION, 1985, 7 (01) :3-12

[3] 3-DIMENSIONAL STRUCTURE OF AN ANTIGEN-ANTIBODY COMPLEX AT 2.8-A RESOLUTION [J].

AMIT, AG ;

MARIUZZA, RA ;

PHILLIPS, SEV ;

POLJAK, RJ .

SCIENCE, 1986, 233 (4765) :747-753

[4]

BAJAJ M, 1984, ANNU REV BIOPHYS BIO, V13, P453

[5] STRUCTURE OF CHICKEN MUSCLE TRIOSE PHOSPHATE ISOMERASE DETERMINED CRYSTALLOGRAPHICALLY AT 2.5A RESOLUTION USING AMINO-ACID SEQUENCE DATA [J].

BANNER, DW ;

BLOOMER, AC ;

PETSKO, GA ;

PHILLIPS, DC ;

POGSON, CI ;

WILSON, IA ;

CORRAN, PH ;

FURTH, AJ ;

MILMAN, JD ;

OFFORD, RE ;

PRIDDLE, JD ;

WALEY, SG .

NATURE, 1975, 255 (5510) :609-614

[6]

BARTON G, IN PRESS PROTEIN ENG

[7] RELAXIN HAS CONFORMATIONAL HOMOLOGY WITH INSULIN [J].

BEDARKAR, S ;

TURNELL, WG ;

BLUNDELL, TL ;

SCHWABE, C .

NATURE, 1977, 270 (5636) :449-451

[8] 3-DIMENSIONAL STRUCTURE, SPECIFICITY AND CATALYTIC MECHANISM OF RENIN [J].

BLUNDELL, T ;

SIBANDA, BL ;

PEARL, L .

NATURE, 1983, 304 (5923) :273-275

[9] INSULIN-LIKE GROWTH-FACTOR - MODEL FOR TERTIARY STRUCTURE ACCOUNTING FOR IMMUNOREACTIVITY AND RECEPTOR-BINDING [J].

BLUNDELL, TL ;

BEDARKAR, S ;

RINDERKNECHT, E ;

HUMBEL, RE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (01) :180-184

[10] 3-DIMENSIONAL STRUCTURAL ASPECTS OF THE DESIGN OF NEW-PROTEIN MOLECULES [J].

BLUNDELL, TL ;

BARLOW, D ;

SIBANDA, BL ;

THORNTON, JM ;

TAYLOR, W ;

TICKLE, IJ ;

STERNBERG, MJE ;

PITTS, JE ;

HANEEF, I ;

HEMMINGS, AM .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES, 1986, 317 (1540) :333-344

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