FACILITATION OF SELF-STIMULATION BEHAVIOR FOLLOWING INTRA-CEREBRAL MICRO-INJECTIONS OF OPIOIDS INTO THE VENTRAL TEGMENTAL AREA

被引:100
作者
BROEKKAMP, CL
PHILLIPS, AG
COOLS, AR
机构
[1] UNIV BRITISH COLUMBIA,DEPT PSYCHOL,VANCOUVER V6T 1W5,BC,CANADA
[2] CATHOLIC UNIV NIJMEGEN,DEPT PHARMACOL,NIJMEGEN,NETHERLANDS
关键词
Enkephalin; Morphine; Naloxone; Rat; Self-stimulation; Ventral tegmental area;
D O I
10.1016/0091-3057(79)90137-0
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The intracerebral microinjection technique was used to localize sites in the brain where morphine facilitated the self-stimulation rate at hypothalamic electrode sites. Bilateral injections of morphine (2×1 μg) into the ventral tegmental area and substantia nigra produced the strongest enhancement at the shortest latencies. At these sites, bilateral injections of 200 ng of morphine also produced a significant enhancement whereas a dose of 50 ng was below threshold for the rate increasing effect. The enhancement by morphine was effectively antagonized by naloxone (5 mg/kg). When injected bilaterally into the same area, D-Ala2-Met5-enkephalinamide (2×1 μg) also induced a strong enhancement of self-stimulation lasting for 70 minutes. A possible dopaminergic substrate for the opiate induced behavioral stimulation is discussed. © 1979.
引用
收藏
页码:289 / 295
页数:7
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