THE DAL81 GENE-PRODUCT IS REQUIRED FOR INDUCED EXPRESSION OF 2 DIFFERENTLY REGULATED NITROGEN CATABOLIC GENES IN SACCHAROMYCES-CEREVISIAE

被引:72
作者
BRICMONT, PA [1 ]
DAUGHERTY, JR [1 ]
COOPER, TG [1 ]
机构
[1] UNIV TENNESSEE, CTR HLTH SCI, DEPT MICROBIOL & IMMUNOL, MEMPHIS, TN 38163 USA
关键词
D O I
10.1128/MCB.11.2.1161
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
We demonstrate that the DAL81 gene, previously thought to be specifically required for induced expression of the allantoin pathway genes in Saccharomyces cerevisiae, functions in a more global manner. The data presented show it to be required for utilization of 4-aminobutyrate as a nitrogen source and for 4-aminobutyrate-induced increases in the steady-state levels of UGA1 mRNA. The DAL81 gene encodes a 970-amino-acid protein containing sequences homologous to the Zn(II)2Cys6 motif and two stretches of polyglutamine residues. Deletion of sequences homologous to the Zn(II)2Cys6 motif did not result in a detectable loss of function. On the other hand, loss of one of the polyglutamine stretches, but not the other, resulted in a 50% loss of DAL81 function.
引用
收藏
页码:1161 / 1166
页数:6
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