CURRENT ADVANCES AND TRENDS IN THE TREATMENT OF DEPRESSION

被引:1033
作者
BLIER, P
DEMONTIGNY, C
机构
[1] Department of Psychiatry, McGill University, Montréal
关键词
D O I
10.1016/0165-6147(94)90315-8
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The pathophysiology of major affective illness is poorly understood. However, several lines of preclinical and clinical evidence indicate that an enhancement of 5-HT-mediated neurotransmission might underlie the therapeutic effect of most antidepressant treatments. This net effect would, however, be obtained via different mechanisms. A better understanding of the neurobiological basis for the delayed onset of action of antidepressant treatments has led to the elaboration of strategies that could accelerate the antidepressant response. These strategies are discussed in this article by Pierre Blier and Claude de Montigny.
引用
收藏
页码:220 / 226
页数:7
相关论文
共 52 条
[1]  
ARTIGAS F, 1994, ARCH GEN PSYCHIAT, V51, P248
[2]   INCREASED ANTIDEPRESSANT USE IN PATIENTS PRESCRIBED BETA-BLOCKERS [J].
AVORN, J ;
EVERITT, DE ;
WEISS, S .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1986, 255 (03) :357-360
[3]   CHRONIC TREATMENT WITH FLUVOXAMINE INCREASES EXTRACELLULAR SEROTONIN IN FRONTAL-CORTEX BUT NOT IN RAPHE NUCLEI [J].
BEL, N ;
ARTIGAS, F .
SYNAPSE, 1993, 15 (03) :243-245
[4]   SEROTONERGIC MECHANISMS IN PSYCHIATRIC-DISORDERS - NEW RESEARCH TOOLS, NEW IDEAS [J].
BENKELFAT, C .
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 1993, 8 :53-56
[5]  
BLIER P, 1990, Journal of Clinical Psychopharmacology, V10, p13S
[6]  
BLIER P, 1993, J PHARMACOL EXP THER, V265, P7
[7]   LONG-TERM 5-HT REUPTAKE BLOCKADE, BUT NOT MONOAMINE-OXIDASE INHIBITION, DECREASES THE FUNCTION OF TERMINAL 5-HT AUTORECEPTORS - AN ELECTROPHYSIOLOGICAL STUDY IN THE RAT-BRAIN [J].
BLIER, P ;
CHAPUT, Y ;
DEMONTIGNY, C .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1988, 337 (03) :246-254
[8]  
BLIER P, 1990, J CLIN PSYCHIAT, V51, P14
[9]   EFFECT OF REPEATED ELECTROCONVULSIVE SHOCKS ON SEROTONERGIC NEURONS [J].
BLIER, P ;
BOUCHARD, C .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 211 (03) :365-373
[10]  
Blier P., 1993, Society for Neuroscience Abstracts, V19, P856