IODINE-125-LABELED ESTRADIOL - GAMMA-EMITTING ANALOG OF ESTRADIOL THAT BINDS TO THE ESTROGEN-RECEPTOR

被引：143

作者：

HOCHBERG, RB ^{[1
]}

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,DEPT OBSTET & GYNECOL,NEW YORK,NY 10032

来源：

SCIENCE | 1979年 / 205卷 / 4411期

关键词：

D O I：

10.1126/science.472733

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

17β-[16α-125I]Iodoestradiol has been synthesized by exchange of 16β-bromoestradiol with Na 125I. The iodinated product is readily separated from the bromo reactant by column chromatography. It concentrates in the rat uterus in vivo and binds avidly and specifically to the uterine estrogen receptor in vitro. Copyright © 1979 AAAS.

引用

页码：1138 / 1140

页数：3

共 23 条

[1]

ALBERT S, 1949, J BIOL CHEM, V177, P247

[2]

COUNSELL RE, 1976, STEROID HORMONE ACTI, P107

[3] PROPERTIES OF A UTERINE OESTRADIOL RECEPTOR [J].

ERDOS, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1968, 32 (02) :338-&

[4] SYNTHESIS OF 1,3,5(10)-ESTRATRIENE-3,16-BETA,17-ALPHA-TRIOL [J].

FISHMAN, J ;

BIGGERSTAFF, WR .

JOURNAL OF ORGANIC CHEMISTRY, 1958, 23 (08) :1190-1192

[5] SYNTHESIS AND NUCLEAR MAGNETIC RESONANCE SPECTRA OF EPIMERIC 16-DEUTERIO-17BETA- AND -17ALPHA-ESTRADIOLS [J].

FISHMAN, J .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1965, 87 (15) :3455-&

[6]

HOCHBERG R, UNPUBLISHED

[7]

JENSEN EV, 1962, RECENT PROG HORM RES, V18, P390

[8] IODOHEXESTROLS .1. SYNTHESIS AND PHOTOREACTIVITY OF IODINATED HEXESTROL DERIVATIVES [J].

KATZENELLENBOGEN, JA ;

HSIUNG, HM .

BIOCHEMISTRY, 1975, 14 (08) :1736-1741

[9] IODOHEXESTROLS .2. CHARACTERIZATION OF BINDING AND ESTROGENIC ACTIVITY OF IODINATED HEXESTROL DERIVATIVES, INVITRO AND INVIVO [J].

KATZENELLENBOGEN, JA ;

HSIUNG, HM ;

CARLSON, KE ;

MCGUIRE, WL ;

KRAAY, RJ ;

KATZENELLENBOGEN, BS .

BIOCHEMISTRY, 1975, 14 (08) :1742-1750

[10]

KOMAI T, 1977, J NUCL MED, V18, P360

← 1 2 3 →