GRAFTS OF FETAL DOPAMINE NEURONS SURVIVE AND IMPROVE MOTOR FUNCTION IN PARKINSONS-DISEASE

被引:945
作者
LINDVALL, O
BRUNDIN, P
WIDNER, H
REHNCRONA, S
GUSTAVII, B
FRACKOWIAK, R
LEENDERS, KL
SAWLE, G
ROTHWELL, JC
MARSDEN, CD
BJORKLUND, A
机构
[1] UNIV LONDON NATL HOSP, INST NEUROL, DEPT CLIN NEUROL, LONDON WC1N 3BG, ENGLAND
[2] DEPT MED CELL RES, S-22362 LUND, SWEDEN
[3] KAROLINSKA INST, HUDDINGE HOSP, DEPT CLIN IMMUNOL, S-14186 HUDDINGE, SWEDEN
[4] UNIV LUND HOSP, DEPT GYNECOL, S-22185 LUND, SWEDEN
[5] HAMMERSMITH HOSP, MRC, CYCLOTRON UNIT, LONDON W12 0HS, ENGLAND
[6] PAUL SCHERRER INST, CH-5232 VILLIGEN, SWITZERLAND
[7] NATL HOSP, MRC, HUMAN MOVEMENT & BALANCE UNIT, LONDON WC1N 3BG, ENGLAND
[8] UNIV LUND HOSP, DEPT NEUROSURG, S-22185 LUND, SWEDEN
关键词
D O I
10.1126/science.2105529
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Neural transplantation can restore striatal dopaminergic neurotransmission in animal models of Parkinson's disease. It has now been shown that mesencephalic dopamine neurons, obtained from human fetuses of 8 to 9 weeks gestational age, can survive in the human brain and produce marked and sustained symptomatic relief in a patient severely affected with idiopathic Parkinson's disease. The grafts, which were implanted unilaterally into the putamen by stereotactic surgery, restored dopamine synthesis and storage in the grafted area, as assessed by positron emission tomography with 6-L-[18F] fluorodopa. This neurochemical change was accompanied by a therapeutically significant reduction in the patient's severe rigidity and bradykinesia and a marked diminuation of the fluctuations in the patient's condition during optimum medication (the "on-off" phenomenon). The clinical improvement was most marked on the side contralateral to the transplant.
引用
收藏
页码:574 / 577
页数:4
相关论文
共 35 条
[1]  
BAKAY RAE, 1985, APPL NEUROPHYSIOL, V48, P358
[2]  
BANKIEWICZ K S, 1988, Society for Neuroscience Abstracts, V14, P3
[3]   PERFORMANCE OF SIMULTANEOUS MOVEMENTS IN PATIENTS WITH PARKINSONS-DISEASE [J].
BENECKE, R ;
ROTHWELL, JC ;
DICK, JPR ;
DAY, BL ;
MARSDEN, CD .
BRAIN, 1986, 109 :739-757
[4]   DISTURBANCE OF SEQUENTIAL MOVEMENTS IN PATIENTS WITH PARKINSONS-DISEASE [J].
BENECKE, R ;
ROTHWELL, JC ;
DICK, JPR ;
DAY, BL ;
MARSDEN, CD .
BRAIN, 1987, 110 :361-379
[5]   RE-INNERVATION OF THE DENERVATED STRIATUM BY SUBSTANTIA NIGRA TRANSPLANTS - FUNCTIONAL CONSEQUENCES AS REVEALED BY PHARMACOLOGICAL AND SENSORIMOTOR TESTING [J].
BJORKLUND, A ;
DUNNETT, SB ;
STENEVI, U ;
LEWIS, ME ;
IVERSEN, SD .
BRAIN RESEARCH, 1980, 199 (02) :307-333
[6]   RECONSTRUCTION OF THE NIGROSTRIATAL DOPAMINE PATHWAY BY INTRA-CEREBRAL NIGRAL TRANSPLANTS [J].
BJORKLUND, A ;
STENEVI, U .
BRAIN RESEARCH, 1979, 177 (03) :555-560
[7]   FUNCTIONAL REACTIVATION OF THE DEAFFERENTED NEOSTRIATUM BY NIGRAL TRANSPLANTS [J].
BJORKLUND, A ;
STENEVI, U ;
DUNNETT, SB ;
IVERSEN, SD .
NATURE, 1981, 289 (5797) :497-499
[8]   ANGIOARCHITECTURE OF THE CNS, PITUITARY-GLAND, AND INTRACEREBRAL GRAFTS REVEALED WITH PEROXIDASE CYTOCHEMISTRY [J].
BROADWELL, RD ;
CHARLTON, HM ;
BALIN, BJ ;
SALCMAN, M .
JOURNAL OF COMPARATIVE NEUROLOGY, 1987, 260 (01) :47-62
[9]   ALLOGRAFTS OF CNS TISSUE POSSESS A BLOOD-BRAIN BARRIER .1. GRAFTS OF MEDIAL PREOPTIC AREA IN HYPOGONADAL MICE [J].
BROADWELL, RD ;
CHARLTON, HM ;
GANONG, WF ;
SALCMAN, M ;
SOFRONIEW, M .
EXPERIMENTAL NEUROLOGY, 1989, 105 (02) :135-151
[10]  
BRUNDIN P, 1986, EXP BRAIN RES, V65, P235