CLONIDINE REVERSAL OF INCREASED NOREPINEPHRINE METABOLITE LEVELS DURING MORPHINE WITHDRAWAL

被引：119

作者：

CRAWLEY, JN ^{[1
]}

LAVERTY, R ^{[1
]}

ROTH, RH ^{[1
]}

机构：

[1] YALE UNIV,SCH MED,DEPT PSYCHIAT,NEW HAVEN,CT 06510

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 57卷 / 2-3期

关键词：

Clonidine; Dopamine; Locus coeruleus; Metabolites; Morphine; Norepinephrine;

D O I：

10.1016/0014-2999(79)90372-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The production of the norepinephrine metabolite 3-methoxy-4-hydroxyphethylenglycol (MHPG) in brain regions innvervated by the locus coeruleus was increased during naloxone-precipitated withdrawal from chronic morphine treatment. This MHPG increases was reversed by subcutaneous administration of clonidine. Changes in MHPG levels paralleled the electrophysiological changes found by Aghajanian (1978) in locus coeruleus firing rate with similar treatments, demonstrating the usefulness of MHPG changes as an index of central noradrenergic function. © 1979.

引用

页码：247 / 250

页数：4

共 10 条

[1]

AGHAJANIAN GK, 1978, NATURE, V276, P5684

[2] 3,4-DIHYDROXYPHENYLACETIC ACID AND HOMOVANILLIC-ACID IN RAT PLASMA - POSSIBLE INDICATORS OF CENTRAL DOPAMINERGIC ACTIVITY [J].