S100-BETA PROTECTS HIPPOCAMPAL-NEURONS FROM DAMAGE-INDUCED BY GLUCOSE DEPRIVATION

被引：121

作者：

BARGER, SW

VANELDIK, LJ

MATTSON, MP

机构：

[1] UNIV KENTUCKY,DEPT ANAT & NEUROBIOL,LEXINGTON,KY 40536

[2] NORTHWESTERN UNIV,DEPT MOLEC & CELL BIOL,CHICAGO,IL 60611

[3] NORTHWESTERN UNIV,INST NEUROSCI,CHICAGO,IL 60611

来源：

BRAIN RESEARCH | 1995年 / 677卷 / 01期

基金：

美国国家卫生研究院;

关键词：

S100; CALCIUM; HIPPOCAMPUS; NEUROTROPHIC; GLUCOSE; MITOCHONDRIA;

D O I：

10.1016/0006-8993(95)00160-R

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

S100 beta is a calcium-binding protein elevated in Down's syndrome and Alzheimer's disease. Previous studies have demonstrated that S100 beta is trophic for several neuronal populations. We tested the influence of S100 beta on hippocampal neurons. The initial response included a rapid increase in [Ca2+](i) similar to that elicited by S100 beta in other populations. S100 beta also substantially decreased cell death and loss of mitochondrial function resulting from glucose deprivation. Therefore, S100 beta exerts a neuroprotective influence on CNS neurons, suggesting that its elevation in neurological disorders may be a compensatory response.

引用

页码：167 / 170

页数：4

共 28 条

[1] S-100B BUT NOT NGF, EGF, INSULIN OR CALMODULIN IS A CNS SEROTONERGIC GROWTH-FACTOR [J].