THE ANGIOTENSIN AT2-RECEPTOR MODULATES T-TYPE CALCIUM CURRENT IN NONDIFFERENTIATED NG108-15 CELLS

被引：129

作者：

BUISSON, B

BOTTARI, SP

DEGASPARO, M

GALLOPAYET, N

PAYET, MD

机构：

[1] UNIV SHERBROOKE, FAC MED, SERV ENDOCRINOL, SHERBROOKE J1H 5N4, QUEBEC, CANADA

[2] CIBA GEIGY AG, DIV PHARMACEUT, CH-4002 BASEL, SWITZERLAND

[3] UNIV SHERBROOKE, FAC MED, DEPT PHYSIOL & BIOPHYS, SHERBROOKE J1H 5N4, QUEBEC, CANADA

来源：

FEBS LETTERS | 1992年 / 309卷 / 02期

关键词：

ANGIOTENSIN; ANGIOTENSIN RECEPTOR; CALCIUM CURRENT; CGP-42112; NEURONAL CELL; NG108-15;

D O I：

10.1016/0014-5793(92)81086-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report here that angiotensin II (AII) and the AT2 receptor-selective ligand, CGP 42112, modulate the T-type calcium current in non-differentiated NG108-15 cells, which express only AT2 receptors. Both peptides decrease the T-type calcium current at membrane potentials above -40 mV and shift the current voltage curve at lower potentials with maximal effect between 5 and 10 min after application. These data describe a new cellular response to AII and suggest that the AT2 receptor mediates certain neurophysiological actions of this hormone.

引用

页码：161 / 164

页数：4

共 41 条

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