BIOPHYSICAL AND MOLECULAR MECHANISMS OF SHAKER POTASSIUM CHANNEL INACTIVATION

被引：1385

作者：

HOSHI, T ^{[1
]}

ZAGOTTA, WN ^{[1
]}

ALDRICH, RW ^{[1
]}

机构：

[1] STANFORD UNIV,MED CTR,SCH MED,DEPT MOLEC & CELLULAR PHYSIOL,STANFORD,CA 94305

来源：

SCIENCE | 1990年 / 250卷 / 4980期

关键词：

D O I：

10.1126/science.2122519

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The potassium channels encoded by the Drosophila Shaker gene activate and inactivate rapidly when the membrane potential becomes more positive. Site-directed mutagenesis and single-channel patch-clamp recording were used to explore the molecular transitions that underlie inactivation in Shaker potassium channels expressed in Xenopus oocytes. A region near the amino terminus with an important role in inactivation has now been identified. The results suggest a model where this region forms a cytoplasmic domain that interacts with the open channel to cause inactivation.

引用

页码：533 / 538

页数：6

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