THE EFFECTS OF CHRONIC ETHANOL-CONSUMPTION ON HEPATIC MITOCHONDRIAL ENERGY-METABOLISM

被引：140

作者：

CUNNINGHAM, CC

COLEMAN, WB

SPACH, PI

机构：

[1] Department of Biochemistry, Wake Forest University Medical Center, Winston-Salem

来源：

ALCOHOL AND ALCOHOLISM | 1990年 / 25卷 / 2-3期

关键词：

D O I：

10.1093/oxfordjournals.alcalc.a044987

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Chronic ethanol consumption results in a generalized depression in hepatic mitochondrial energy metabolism. Both the rate and efficiency of ATP synthesis via the oxidative phosphorylation system are decreased. Alterations in the activities of several components of the oxidative phosphorylation system contribute to the overall decrease in the capacity for ATP synthesis. There appears to be no alteration in any particular component which is rate-limiting. Although changes in membrane lipids may play a minor role, it appears that the decreased levels of mitochondria-derived polypeptide components of the oxidative phosphorylation system are primarily responsible for the depression in both the rate and efficiency of ATP synthesis. The concentrations of these mitochondrial gene products are lowered due to effects of chronic ethanol consumption on the mitochondrial translational process. © 1990 Medical Council on Alcoholism.

引用

页码：127 / 136

页数：10

共 40 条

[1] DECREASED CYTOCHROME-OXIDASE ACTIVITY IN HEPATIC MITOCHONDRIA AFTER CHRONIC ETHANOL-CONSUMPTION AND THE POSSIBLE ROLE OF DECREASED CYTOCHROME-AA3 CONTENT AND CHANGES IN PHOSPHOLIPIDS [J].