YEAST ARTIFICIAL CHROMOSOME-BASED GENOME MAPPING - SOME LESSONS FROM XQ24-Q28

被引：85

作者：

SCHLESSINGER, D ^{[1
]}

LITTLE, RD ^{[1
]}

FREIJE, D ^{[1
]}

ABIDI, F ^{[1
]}

ZUCCHI, I ^{[1
]}

PORTA, G ^{[1
]}

PILIA, G ^{[1
]}

NAGARAJA, R ^{[1
]}

JOHNSON, SK ^{[1
]}

YOON, JY ^{[1
]}

SRIVASTAVA, A ^{[1
]}

KERE, J ^{[1
]}

PALMIERI, G ^{[1
]}

CICCODICOLA, A ^{[1
]}

MONTANARO, V ^{[1
]}

ROMANO, G ^{[1
]}

CASAMASSIMI, A ^{[1
]}

DURSO, M ^{[1
]}

机构：

[1] INT INST GENET & BIOPHYS,I-80125 NAPLES,ITALY

来源：

GENOMICS | 1991年 / 11卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0888-7543(91)90001-U

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Yeast artificial chromosomes (YACs) have recently provided a potential route to long-range coverage of complex genomes in contiguous cloned DNA. In a pilot project for 50 Mb (1.5% of the human genome), a variety of techniques have been applied to assemble Xq24-q28 YAC contigs up to 8 Mb in length and assess their quality. The results indicate the relative strength of several approaches and support the adequacy of YAC-based methods for mapping the human genome. © 1991.

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收藏

页码：783 / 793

页数：11

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