QUANTITATION OF VENTRICULAR SIZE IN NORMAL AND SPONTANEOUSLY HYPERTENSIVE RATS BY MAGNETIC-RESONANCE-IMAGING

被引：42

作者：

BENDEL, P ^{[1
]}

EILAM, R ^{[1
]}

机构：

[1] WEIZMANN INST SCI,DEPT NEUROBIOL,IL-76100 REHOVOT,ISRAEL

来源：

BRAIN RESEARCH | 1992年 / 574卷 / 1-2期

关键词：

MAGNETIC RESONANCE IMAGING; BRAIN VENTRICULAR DILATION; SPONTANEOUSLY HYPERTENSIVE RAT; WYSTAR-KYOTO RAT;

D O I：

10.1016/0006-8993(92)90820-Y

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Magnetic resonance imaging (MRI) performed at high field (4.7 Tesla), and high spatial resolution (0.6 mm slice thickness, 0.18 mm inplane) enabled noninvasive quantitative measurement of the ventricular vol. in live rats. Comparing the results for 15 male Wystar-Kyoto (WKY) rats, aged 2.5-10 months, with those from 17 spontaneously hypertensive rats (SHR), clearly confirmed the previously reported elevated ventricular vols. in the SHR strain. A significant difference in ventricular vol. between the two strains was detected above the age of 3 months. For mature animals above the age of 6 months the mean vol. in the SHR strain was elevated by about a factor of two compared to the WKY control animals.

引用

页码：224 / 228

页数：5

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