PLATELET AGGREGATION .I. REGULATION BY CYCLIC AMP AND PROSTAGLANDIN E1

被引：170

作者：

MARQUIS, NR

VIGDAHL, RL

TAVORMINA, PA

机构：

[1] Department of Biochemistry Mead Johnson Research Center, Evansville, IN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 36卷 / 06期

关键词：

D O I：

10.1016/0006-291X(69)90298-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aggregation of human platelets is inhibited by cyclic AMP and by its dibutyryl derivative. Prostaglandin E1 (PGE1) inhibits platelet aggregation and stimulates cyclic AMP synthesis by human platelet membrane fractions apparently by stimulation of adenyl cyclase. Caffeine, in contrast, inhibits platelet phosphodiesterase resulting in increased cyclic AMP levels; PGE1 and caffeine are synergistic. PGA1 and PGF1α are also active but at higher concentrations. © 1969.

引用

页码：965 / +

页数：1

共 12 条

[1]

BERGSTROM S, 1968, PHARMACOL REV, V20, P1

[2]

BORN GVR, 1963, J PHYSIOL-LONDON, V168, P178, DOI 10.1113/jphysiol.1963.sp007185

[3]

BUTCHER RW, 1967, PHARMACOLOGIST, V9, P172

[4] EFFECT OF PROSTAGLANDIN E1 ON PLATELET BEHAVIOUR IN VITRO AND IN VIVO [J].

EMMONS, PR ;

HAMPTON, JR ;

HARRISON, MJ ;

HONOUR, AJ ;

MITCHELL, JR .

BRITISH MEDICAL JOURNAL, 1967, 2 (5550) :468-&

[5]

KLOEZE J, 1966, 2 P NOB S STOCKH

[6]

KRISHNA G, 1968, J PHARMACOL EXP THER, V163, P379

[7]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[8]

MARQUIS NR, IN PRESS

[9]

ROBISON GA, 1968, ANN REV BIOCHEM, V149

[10]

VIGDAHL RL, IN PRESS

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