GENETIC-ASPECTS OF ANTIBIOTIC INDUCED DEAFNESS - MITOCHONDRIAL INHERITANCE

被引：109

作者：

HU, DN

QIU, WQ

WU, BT

FANG, LZ

ZHOU, F

GU, YP

ZHANG, QH

YAN, JH

DING, YQ

WONG, H

机构：

[1] TIEDAO MED COLL,NATL CTR GENET MED,DEPT GENET COUNSELLING,SHANGHAI,PEOPLES R CHINA

[2] ZHABEI EYE HOSP,DEPT POPULAT GENET,SHANGHAI,PEOPLES R CHINA

[3] ZHABEI CENT HOSP,DEPT OTORHINOLARYNGOL,SHANGHAI,PEOPLES R CHINA

[4] TIEDAO MED COLL,DEPT MED GENET,SHANGHAI,PEOPLES R CHINA

来源：

JOURNAL OF MEDICAL GENETICS | 1991年 / 28卷 / 02期

关键词：

D O I：

10.1136/jmg.28.2.79

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Analysis of 36 pedigrees with a positive family history of aminoglycoside antibiotic induced deafness, ascertained in a population of 483 611 in Zhabei District in Shanghai, showed that the susceptibility to antibiotic ototoxicity was transmitted by females exclusively, indicating mitochondrial inheritance. Reanalysis of 18 other published pedigrees confirmed this conclusion.

引用

页码：79 / 83

页数：5

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