BLOOD TO BRAIN TRANSPORT OF INTERLEUKIN LINKS THE IMMUNE AND CENTRAL NERVOUS SYSTEMS

被引：140

作者：

BANKS, WA ^{[1
]}

KASTIN, AJ ^{[1
]}

机构：

[1] TULANE UNIV, SCH MED, NEW ORLEANS, LA 70146 USA

来源：

LIFE SCIENCES | 1991年 / 48卷 / 25期

关键词：

D O I：

10.1016/0024-3205(91)90385-O

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Interleukins (IL) are naturally occurring proteins that regulate, and thus link, both the immune system and the central nervous system (CNS). Since proteins are assumed not to be able to cross the blood-brain barrier (BBB), it is controversial how this linkage could occur. We show here that after iv injection of I-125-hIL-1-alpha, radioactivity in the brain eluted on HPLC in the position of the labeled cytokine. In addition, entry was inhibited by unlabeled hIL-1-alpha. Our demonstration of a saturable, carrier-mediated system that transports recombinant human IL-1-alpha in intact form from the blood into the CNS indicates a direct immune-CNS connection.

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页码：PL117 / PL121

页数：5

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