EFFECTS OF SUPEROXIDE RADICALS ON TRANSPORT (NA+K) ADENOSINE-TRIPHOSPHATASE AND PROTECTION BY SUPEROXIDE-DISMUTASE

被引：74

作者：

HEXUM, TD ^{[1
]}

FRIED, R ^{[1
]}

机构：

[1] CREIGHTON UNIV,SCH MED,DEPT BIOCHEM,OMAHA,NE 68178

来源：

NEUROCHEMICAL RESEARCH | 1979年 / 4卷 / 01期

关键词：

D O I：

10.1007/BF00963833

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Membrane (Na+K)ATPase isolated from rat brain was preincubated in a medium in which superoxide radicals were generated enzymatically. Exposure to superoxide radicals caused an irreversible inactivation, which could be prevented by further addition of superoxide dismutase. (Na+K)ATPase was also protected by addition of allopurinol, a xanthine oxidase inhibitor, during preincubation. The K-activated nitrophenylphosphatase associated with (Na+K)ATPase was also found to be inactivated by preincubation with superoxide radicals, which could be prevented by superoxide dismutase. © 1979 Plenum Publishing Corporation.

引用

页码：73 / 82

页数：10

共 28 条

[1] EFFECTS OF CHLORPROMAZINE FREE-RADICAL ON BRAIN MICROSOMAL ENZYMES [J].