RECEPTOR-MEDIATED ENDOCYTOSIS - INSIGHTS FROM THE LIPOPROTEIN RECEPTOR SYSTEM

被引:672
作者
BROWN, MS [1 ]
GOLDSTEIN, JL [1 ]
机构
[1] UNIV TEXAS, HLTH SCI CTR, DEPT INTERNAL MED, DALLAS, TX 75235 USA
关键词
D O I
10.1073/pnas.76.7.3330
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
The low density lipoprotein (LDL) receptor system coordinates the metabolism of cholesterol, an essential component of the plamsa membrane of all mammalian cells. Study of this system has led to an enhanced understanding of the cellular basis of cholesterol homeostasis. It has also brought into focus an important mechanism of metabolic regulation - the process of receptor-mediated endocytosis. In this article, we first describe the receptor-mediated endocytosis of LDL, a sequence of events in which receptor binding and internalization are coupled in specialized regions of the plasma membrane called coated pits. Second, we trace the cellular functions of the cholesterol derived from internalized LDL. Third, genetic evidence is presented to indicate that both the binding and internalization of LDL are mediated by a single receptor molecule that contains two active sites, one mediating binding and the other internalization. Finally, the characteristics of the LDL receptor system are used to suggest models for receptor systems in general.
引用
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页码:3330 / 3337
页数:8
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