DOPAMINERGIC INTERACTION WITH THE RESPIRATORY CONTROL-SYSTEM IN THE RAT

被引：62

作者：

LUNDBERG, D

BREESE, GR

MUELLER, RA

机构：

[1] UNIV N CAROLINA,SCH MED,BIOL SCI RES CTR,DEPT PSYCHIAT,CHAPEL HILL,NC 27514

[2] UNIV N CAROLINA,SCH MED,BIOL SCI RES CTR,DEPT PHARMACOL,CHAPEL HILL,NC 27514

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 54卷 / 1-2期

关键词：

Carbon dioxide; Dopamine; Haloperidol; Minute ventilation; Respiration;

D O I：

10.1016/0014-2999(79)90417-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Apomorphine given to rats lightly anesthetized with halothane produces as dose dependent increase in respiratory frequency and minute ventilation. Although basal arterial CO2 tensions were not significantly altered by apomorphine, the mechanical response to exogenous CO2 exposure was greatly increased in rats given apomorphine. Haloperidol returned the apomorphine-stimulated respiratory pattern to control values. It is concluded that dopamine neurons may have important interactions with respiratory control. © 1979.

引用

页码：153 / 159

页数：7

共 12 条

[1]

ARMIJO JA, 1974, NEUROPHARMACOLOGY, V13, P977

[2]

BIGGIO G, 1977, J PHARMACOL EXP THER, V200, P207

[3]

Bolme P, 1977, Adv Biochem Psychopharmacol, V16, P281

[4] POSSIBLE INVOLVEMENT OF CENTRAL ADRENALIN NEURONS IN VASOMOTOR AND RESPIRATORY CONTROL - STUDIES WITH CLONIDINE AND ITS INTERACTIONS WITH PIPEROXANE AND YOHIMBINE [J].